Calixtyrosol: a Novel Calixarene Based Potent Radical Scavenger

نویسندگان

  • Fazel Nasuhipur Health Technology Incubator Center, Urmia University of Medical Science
چکیده مقاله:

The oxidative stress causes many diseases in human, therefore antioxidants have a specialposition in the medicinal chemistry. Tyrosol is an important antioxidant with a plenty ofbiological properties. There are many strategies such as clustering single drug units in orderto develop new drugs. The cluster effect can increase drug effects relative to single drug unit.Calixtyrosol is the novel cluster of tyrosol that shows a more effective antioxidant activity thansingle tyrosol. In fact, tyrosol can be considered as 1/4 of the cluster.Four hydroxyethyl moieties have been grafted at the upper rim of the calix[4]arene in allsynorientation, giving novel agent in the field of antioxidant agents. Free radical scavengingtests were determined by the 2, 2-diphenyl-1-picrylhydrazyl radical in methanol for fourantioxidants: calixtyrosol, tyrosol, hydroxytyrosol and 3, 5-di-tert-buty l-4-hydroxytoluene tocompare their antioxidant activity.Free radical scavenging test showed that calixtyrosol has enhanced antioxidant activity incomparison to the corresponding single tyrosol unit (> 5 fold), it has even more active than theother test antioxidants (2 fold). Presumably, it is attributed to tethering and arraying of fourimpacted tyrosol units, which make a synergistic effect in interactions with radicals for creatingeffective radical scavenging activity.This method is in debt of synergistic effect, tethering and arraying of single units in thecluster structure.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

calixtyrosol: a novel calixarene based potent radical scavenger

the oxidative stress causes many diseases in human, therefore antioxidants have a specialposition in the medicinal chemistry. tyrosol is an important antioxidant with a plenty ofbiological properties. there are many strategies such as clustering single drug units in orderto develop new drugs. the cluster effect can increase drug effects relative to single drug unit.calixtyrosol is the novel clu...

متن کامل

Calixarbutin: A Novel Calixarene-based Potential Water-soluble Anti-tyrosinase Agent with High Anti-melanoma Activity

Since melanocytes are the origin of melanoma and some skin disorders such as melasma, they are important cells from the perspective of medicinal chemistry. Therefore, a medication that can simultaneously overcome these diseases will be a successful potential therapeutic agent. Arbutin with phenolic structure is a powerful natural anti-tyrosinase agent. Hence, the phenolic structure of this drug...

متن کامل

Calixarbutin: A Novel Calixarene-based Potential Water-soluble Anti-tyrosinase Agent with High Anti-melanoma Activity

Since melanocytes are the origin of melanoma and some skin disorders such as melasma, they are important cells from the perspective of medicinal chemistry. Therefore, a medication that can simultaneously overcome these diseases will be a successful potential therapeutic agent. Arbutin with phenolic structure is a powerful natural anti-tyrosinase agent. Hence, the phenolic structure of this drug...

متن کامل

Calixapap: Calixarene-based Cluster of Acetaminophen as a Novel Antiradical Agent

In this paper, the synthesis and free-radical scavenging capacity of novel calix[4]arene-based cluster of paracetamol was reported. The phenolic structures of acetaminophen and calix[4]arene prompted us for designing a synthetic route for calix[4]arene-based cyclic tetramer of paracetamol. The present chalice-shaped cluster is the first example of calixarene/acetaminophen hybrid and paracetamol...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 14  شماره 4

صفحات  1181- 1187

تاریخ انتشار 2015-10-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023